Preparation and quality evaluation of Acori Tatarinowii Rhizoma-volatile oil microemulsion
10.7501/j.issn.0253-2670.2019.08.024
- Author:
Shao-Lin LI
1
Author Information
1. Guangdong Food and Drug Vocational College
- Publication Type:Journal Article
- Keywords:
Acori Tatarinowii Rhizoma;
In vitro transdermal penetration;
Microemulsion;
Pseudo-ternary phase diagram;
Volatile oil
- From:
Chinese Traditional and Herbal Drugs
2019;50(8):1935-1941
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Taking the volatile oil of Acori Tatarinowii Rhizoma with the effect of anti-senile dementia as model drug to prepare Acori Tatarinowii Rhizoma-volatile oil microemulsion (AO-ME). Methods: The composition of microemulsion was preliminarily determined according to the solubility of volatile oil from Acori Tatarinowii Rhizoma in various solvents. By drawing pseudo-ternary phase diagram, the optimal microemulsion formulation was selected according to the size of particles and microemulsion region, stability of preparations and drug loading. Results: The optimal microemulsion formulation was that volatile oil of Acori Tatarinowii Rhizoma-Cremophor EL-glycerol-water was 6.25:20.83:10.42:62.5. The average particle size of AO-ME was (30.5 ± 0.2) nm with a polydispersity index of 0.150 ± 0.002. The viscosity value of AO-ME was (2.80 ± 0.21) mPa∙s. In vitro transdermal rate of AO-ME was (1 288.76 ± 16.20) μg/(cm2∙h), measured in β-asarone. Compared with ordinary emulsion, the transdermal rate of AO-ME was increased 14 times. The ciliary toxicity test of toad showed that the preparation had no significant toxicity. Conclusion: The preparation of AO-ME was prepared with stable physicochemical properties, good transdermal properties, and low toxicity to nasal mucosa cilia.
