Spectrum-effect relationship of angiogenesis activity and cardioprotection of water-soluble components of Salvia miltiorrhiza in zebrafish
10.7501/j.issn.0253-2670.2019.12.023
- Author:
Long-Fei YANG
1
Author Information
1. Shandong University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Alkannic acid;
Angiogenesis activity;
Grey correlation degree analysis;
Heart protection;
Spectrum-effect relationship;
Water-soluble components of Salvia miltiorrhiza;
Zebrafish
- From:
Chinese Traditional and Herbal Drugs
2019;50(12):2899-2907
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the spectrum-effect relationship of angiogenesis activity and protective effect of heart injury of water-soluble components of Salvia miltiorrhiza to reveal the pharmacodynamics material basis. Methods: The HPLC fingerprints of water-soluble components of S. miltiorrhiza were established to evaluate the angiogenesis activity and protective effect of heart injury of water-soluble components of S. miltiorrhiza by establishing different models of zebrafish. The spectrum-effect relationship of angiogenesis activity and protective effect of heart injury of water-soluble components of S. miltiorrhiza was established by grey correlation degree analysis. Results: Nine water-soluble components in the fingerprints were positively correlated with efficacy of medicine, the association trend of common peaks and efficacy was consistent, and peak 5 (alkannic acid) played the most significant role among nine components. Conclusion: Elucidation of the material basis of angiogenesis activity and protective effect of heart injury of water-soluble components of S. miltiorrhiza by researching on the spectrum-effect relationship will provide the basis for the deep research of S. miltiorrhiza.
