Integrated analysis of “eighteen incompatible medicaments” of Chinese materia medica based on supramolecular imprinting interaction
10.7501/j.issn.0253-2670.2019.12.004
- Author:
Qi-Meng FAN
1
Author Information
1. College of Pharmacy, Hunan University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Chinese materia medica compatibility;
Eighteen incompatible medicaments;
Imprinting interaction;
Supramolecular chemistry;
Toxicity mechanism
- From:
Chinese Traditional and Herbal Drugs
2019;50(12):2777-2784
- CountryChina
- Language:Chinese
-
Abstract:
The “eighteen incompatible medicaments” is an important content of Chinese materia medica (CMM) compatibility contraindication, involving the key basic problem of safe and effective clinical use of CMM. Based on the rule of the automatic action of supramolecular “imprinting template” previously proposed, the current research basis of “eighteen incompatible medicaments” were integrated and analyzed. Firstly, the history of “eighteen incompatible medicaments” were summarized, then the theory of Chinese materia medica (CMM) compatibility was interpreted by supramolecular “imprinting template”: the compatibility of CMM are that two or more than two kinds of CMM effective components group of molecules (object) are combined by non-covalent bonds, and the new formed supramolecular system and the human body (subject) are interacted with each other according to “imprinting template”, and then the toxicity and efficacy were generated, while the compatibility law of CMM is displayed macroscopically. Based on this, three groups of “eighteen incompatible medicaments” were discussed from the perspective of supramolecular chemistry, and the supramolecular method integrating toxicity with efficacy was put forward, including “chemicalkinetics”, “network kinetics” and “spectrum toxicity and efficacy kinetics” methods, thereby providing the ideas and reference for the research on the mechanism of “eighteen incompatible medicaments” and providing reference for clinical application.
