Research progress on mechanism and signaling pathway regulation of Chinese materia medica on asthma
10.7501/j.issn.0253-2670.2019.15.028
- Author:
Ya-Hui DUAN
1
Author Information
1. Modern Research Center for Traditional Chinese Medicine, Shanxi University
- Publication Type:Journal Article
- Keywords:
Asthma;
Chinese materia medica;
MAPK pathway;
NF-κB pathway;
Notch pathway;
PI3K/Akt pathway;
Signaling pathway;
TGF-β pathway;
Wnt pathway
- From:
Chinese Traditional and Herbal Drugs
2019;50(15):3700-3706
- CountryChina
- Language:Chinese
-
Abstract:
Asthma is a chronic airway inflammation caused by a variety of factors, involving a variety of cells and cellular components, which is often accompanied by airway hyperresponsiveness and airway remodeling. At present, asthma has become a common chronic respiratory disease. There exists close relationship between the asthma and signaling pathways. MAPK, PI3K/Akt, NF-κB, TGF-β, Notch and Wnt pathways related to the asthma were extensively studied currently. Traditional Chinese medicine shows advantages in the treatment of chronic diseases such as asthma. In order to explain the advantages of traditional Chinese medicine in the treatment of asthma and develop new asthma drugs originated from traditional Chinese medicine, the role of traditional Chinese medicine in the intervention of related signaling pathways of asthma was reviewed. In addition, the relationship between signaling pathway and pathogenesis (airway inflammation, airway hyperresponsive, and airway remodeling) were also discussed.
