Optimization of extraction technology and inclusion process of volatile oil for Qingxiangrukang Granules based on Box-Behnken and PCA-G1-entropy method and orthogonal design
10.7501/j.issn.0253-2670.2019.15.017
- Author:
Ya-Tian YU
1
Author Information
1. College of Pharmacy, Chengdu University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Box-Behnken;
Extraction technology;
Inclusion process;
PCA-G1-entropy method;
Qingxiangrukang Granules;
Volatile oil
- From:
Chinese Traditional and Herbal Drugs
2019;50(15):3631-3636
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To optimize the extraction technology and inclusion process of volatile oil for Qingxiangrukang Granules (QG). Methods: Box-Behnken was used to optimize the extraction technology of volatile oil in QG. With yield of inclusion compound and inclusion rate of volatile oil-β-CD as evaluation indexes, and with volatile oil-pure water ratio, β-CD-volatile oil ratio, and inclusion time as investigate factors, the optimal inclusion technology for volatile oil of QG was ensured based on PCA-G1-entropy method and orthogonal design and by using colloid milling. Results: The optimum extraction technology of volatile oil were as follows: extracting time was 6 h, liquid-material ratio was 10, immersion was 0 h. The optimal inclusion technology for volatile oil were as follows: pure water-volatile oil ratio was 1:80, β-CD-volatile oil ratio was 6 g, and the inclusion time was 30 min. Under such condition, there was no significant difference between verification groups of three batches. Conclusion: This optimal extraction technology and inclusion process is stable and workable and can provide experimental basis for industrial production of QG.
