Study on rationality of anti-inflammatory effect of Shufeng Jiedu Capsule on pneumonia rats
10.7501/j.issn.0253-2670.2019.15.004
- VernacularTitle: 疏风解毒胶囊对肺炎大鼠抗炎作用的配伍合理性研究
- Author:
Hai-Yan BI
1
Author Information
1. College of Pharmacy, Anhui Medical University
- Publication Type:Journal Article
- Keywords:
Anti-inflammatory effect;
Bacterial count;
Basophil;
COX-2;
Eosinophil;
Leukocyte;
NF-κB;
Shufeng Jiedu Capsule
- From:
Chinese Traditional and Herbal Drugs
2019;50(15):3541-3546
- CountryChina
- Language:Chinese
-
Abstract:
Objective: In order to investigate the effect of Shufeng Jiedu Capsule (SJC) compatibility on anti-inflammation of pneumonia model rats. SJC whole prescription and its components with effect of heat-clearing and toxin-removing and exterior-releasing were studied. Methods: The pneumonia model of rats induced by Streptococcus pneumoniae was used, divided into control group, model group, cephalexin group, SJC whole prescription group (whole prescription group), SJC exterior-releasing group (exterior-releasing group), and SJC heat-clearing and toxin-removing group (heat clearing and detoxifying group). After administration for 6 d, the colony count of peripheral blood and alveolar lavage fluid (BALF), the number of white blood cell (WBC) and its classification in peripheral blood and alveolar lavage fluid, the contents of nuclear transcription factor-kappa B (NF-κB) and cyclooxygenase (COX-1 and COX-2) were tested to evaluate the compatibility rationality. Results: Compared with model group, the whole prescription group, exterior-releasing group, and heat-clearing and toxin-removing group significantly reduced the colony count of peripheral blood and alveolar lavage fluid, significantly reduced the number of WBC in peripheral blood, significantly increased the proportion of eosinophils and reduced the proportion of basophils. The Q values of rats in the whole prescription group were beyond 1 on two indicators, which were the number of WBC and the proportion of eosinophils. The number of WBC in alveolar lavage fluid and the contents of NF-κB and COX-2 decreased significantly in the whole prescription group, exterior-releasing group and heat-clearing and toxin-removing group. Conclusion: SJC has significant anti-inflammatory effect and therapeutic effect on Streptococcus pneumoniae infection in rats. The exterior-relieving component and the heat-clearing and toxin-removing component have significant synergistic effects.
