The Effects of the Heparin-Coated Maximum Arterial Re-Creation (MAC) Stent on Porcine Coronary Stent Restenosis.
10.4070/kcj.1999.29.5.498
- Author:
Hyung Wook PARK
;
Myung Ho JEONG
;
Yang Soo JANG
;
Yong Rok KIM
;
Wan KIM
;
Woo Suck PARK
;
Nam Ho KIM
;
Joon Woo KIM
;
Sung Hee KIM
;
Jang Hyun CHO
;
Young Keun AHN
;
Jung Gwan CHO
;
Dong Lyun CHO
;
Hyun Jin KIM
;
Jong Chun PARK
;
Jae Hyuck LEE
;
Chang Soo PARK
;
Jung Chaee KANG
- Publication Type:Original Article
- Keywords:
Heparin-coated stent;
Stent Restenosis
- MeSH:
Arteries;
Constriction, Pathologic;
Coronary Angiography;
Coronary Vessels;
Follow-Up Studies;
Heparin;
Incidence;
Plasma;
Polymerization;
Polymers;
Stents*;
Thrombosis
- From:Korean Circulation Journal
1999;29(5):498-506
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Stent thrombosis and late restenosis are still major limitations in the clinical use of coronary stenting. Heparin-coated stent may reduce the incidences of stent thrombosis and restenosis. Heparin-coated stents were compared with control stents in a porcine coronary stent restenosis model in order to evaluate the effects of heparin-coated stent on stent restenosis. METHODS: Heparin was coated on a stent by deposition of an ultra-thin polymeric film containing amine groups by means of plasma polymerization. And then stent was immersed in heparin solution. Stent overdilation injury (stent:artery=1.3:1.0) was performed with bare (Group I, n=4) and heparin-coated (Group II, n=5) MAC stents in porcine coronary arteries. Follow-up quantitative coronary angiography (QCA) was performed at 4 weeks after stenting. The histopathologic assessments (KERN=*)of stented porcine coronary arteries were compared in between 2 groups. RESULTS: 1)Luminal area of stented artery was 7.05+/-1.25 mm2 in Group I and 7.67+/-2.85 mm2 in Group II, which were not different between two Groups. 2)Histopathologic stenosis of Group I was 35.7+/-13.2%, which was higher than 28.6+/-14.7% of Group II (p<0.05). Ratio of neointima/media was 1.16+/-0.52 in Group I and 0.87+/-0.31 in Group II and neointimal area was higher in Group I than in Group II (3.81+/-1.78 mm2 vs. 2.82+/-1.11 mm2, p<0.05 respectively). 3)PCNA (Proliferating cell nuclear antigen) index of GroupI was 10.0+/-2.2%, which was higher than in Group II (6.8+/-4.0%). CONCLUSIONS: Heparin-coated MAC stent may be effective in the inhibition of neointimal proliferation in a porcine stent restenosis model.
