Preparation of silymarin-SBE-β-CD inclusion complex
10.7501/j.issn.0253-2670.2019.17.014
- Author:
Gui-Zhi ZHOU
1
Author Information
1. School of Pharmacy, Fujian University of Chinese Traditional Medicine
- Publication Type:Journal Article
- Keywords:
Infrared spectrum analysis;
Orthogonal design;
Phase solubility;
SBE-β-CD;
Silymarin;
X-ray diffraction analysis
- From:
Chinese Traditional and Herbal Drugs
2019;50(17):4100-4107
- CountryChina
- Language:Chinese
-
Abstract:
Objective: The inclusion compound of silymarin-SBE-β-CD was prepared. Methods: Phase solubility method was used to screen the inclusion materials of cyclodextrin and determine the type of inclusion. The technological conditions of silymarin inclusion complex were optimized by orthogonal design. The solubility of inclusion was determined and its structure was characterized by means of microscope, infrared spectrum analysis and X-ray diffraction analysis. Results: Due to its higher solubilization effect on silymarin, SBE-β-CD was determined as inclusion material. The ratio of drug to cyclodextrin was coated in the mode of 1:n. The process optimized by orthogonal design was as follow: molar ratio of silymarin to SBE-β-CD of 1:8, inclusion temperature of 60 ℃, and inclusion time of 3 h. Microscope, infrared spectrum analysis and X-ray diffraction analysis showed that the inclusion compound was formed and the drug existed in the inclusion compound as amorphous. Conclusion: The inclusion compound of silymarin-SBE-β-CD has been successfully prepared, which can significantly improve the solubility of the drug, and provide experimental basis for its clinical application.
