Chinese materia medica-A natural bioactive oligopeptides bank
10.7501/j.issn.0253-2670.2019.18.030
- Author:
Wen-Bo GUO
1
Author Information
1. College of Traditional Chinese Medicine, Beijing University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Active oligopeptide;
Anti-oxidation activity;
Anticoagulation activity;
Antitumor activity;
Biological activity;
Chinese materia medica;
Immunity enhancement activity;
Liver protection activity;
Neuroprotection activity;
Sequence
- From:
Chinese Traditional and Herbal Drugs
2019;50(18):4477-4484
- CountryChina
- Language:Chinese
-
Abstract:
Oligopeptides are simple in composition, high in safety index and good in drug preparation, which are important components of biomedicine. However, due to the limitation of oligopeptide drug design theory and discovery pathways which are far less than other structural drugs, obtaining new bioactive oligopeptides is a hot and difficult topic in this field. As a natural oligopeptide library, Chinese materia medica (CMM) contains a large number of active oligopeptides. Oligopeptides of CMM have vital biological activities such as neuroprotection activity, liver protection activity, antitumor, anticoagulation, anti-oxidation, immunity enhancement, etc. In this paper, the sequence and biological activity of active oligopeptides discovered by scholars at home and abroad in the past 10 years were reviewed, and the relationship between active oligopeptides and classification of CMM was explored. It is preliminarily suggested that CMM such as tonifying deficiency drugs and promoting blood circulation and removing blood stasis are the sources of natural oligopeptides. There are many research results easy to be successful in the research and development of new oligopeptide drugs, which provides directions and ideas for the development of new active oligopeptide drugs.
