Research progress on regulation and construction of bone marrow hematopoietic niche by traditional Chinese medicine
10.7501/j.issn.0253-2670.2019.18.029
- Author:
Feng-Lin SHEN
1
Author Information
1. Heilongjiang University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Bone marrow hematopoietic niche;
Chinese materia medica components;
Chinese materia medica formula;
Hematologic disease;
Regulation and construction;
Traditional Chinese medicine
- From:
Chinese Traditional and Herbal Drugs
2019;50(18):4470-4476
- CountryChina
- Language:Chinese
-
Abstract:
The bone marrow hematopoietic niche is the place where hematopoietic stem cells and progenitors survive. It is not only related to the hematopoiesis function, but also its steady-state disorders and abnormalities can induce a variety of hematologic diseases, which will even be adapted by malignant cells such as leukemia stem cells, so as to cause seriously poor prognosis. Therefore, it is of great significance to the regulation and construction of the bone marrow niche. In this review, we outline the composition, physiological and pathological basis of bone marrow hematopoietic niche, from the regulation of Chinese materia medica components and TCM formula to graphically analyze the target and effect of drug efficacy. Then, combined with the clinical practice for integrating and summarizing decentralized research, aiming to provide new directions and perspectives for the TCM research and treatment of hematologic diseases.
