Analysis of quality marker in Naozhenning Granule based on “five principles”

VernacularTitle: 基于”五原则”的脑震宁颗粒质量标志物(Q-marker)的辨识分析
Author: Jian-Hua CAO ¹
Author Information

1. Modern Research Center for Traditional Chinese Medicine, Shanxi University
Publication Type:Journal Article
Keywords: Five principles; Naozhenning Granule; Network construction; Quality control; Quality marker (Q-marker)
From: Chinese Traditional and Herbal Drugs 2019;50(19):4654-4662
CountryChina
Language:Chinese
Abstract: Naozhenning Granule (NG) is a traditional Chinese medicine prescription, which can cool and activate blood, resolve stasis and dredge collaterals, enrich blood and tranquilize mind, calm nerves and arrest vomiting. The clinical studies have also confirmed that NG was effective for the treatment of headache, dizziness, irritability, insomnia, forgetfulness, nausea, and vomiting caused by cerebral trauma. The quality markers (Q-markers) of NG are predicted and analyzed based on the “five principles” of Q-markers of Chinese materia medica and the research literatures in the recent years. The modern pharmacological research of the selected Q-markers was reviewed and analyzed. Then the network of “Q-marker, targets, pathway, and disease” was constructed, in order to provide the scientific basis for the quality control study of NG.