Nitroglycerin-Challenged Tc-99m MIBI Quantitative Gated SPECT to Predict Functional Recovery After Coronary Artery Bypass Surgery.
- Author:
Dong Soo LEE
1
;
Yu Kyeong KIM
;
Gi Jeong CHEON
;
Jin Chul PAENG
;
Myoung Mook LEE
;
Ki Bong KIM
;
June Key CHUNG
;
Myung Chul LEE
Author Information
1. Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea. dsl@plaza.snu.ac.kr
- Publication Type:Original Article
- Keywords:
Quantitative gated myocardial SPECT;
nitroglycerin;
rest-redistribution Tl-201 SPECT
- MeSH:
Administration, Sublingual;
Coronary Artery Bypass*;
Coronary Artery Disease;
Coronary Vessels*;
Dipyridamole;
Follow-Up Studies;
Humans;
Myocardium;
Nitroglycerin;
Perfusion;
ROC Curve;
Sensitivity and Specificity;
Thallium;
Tomography, Emission-Computed, Single-Photon*;
Transplants
- From:Korean Journal of Nuclear Medicine
2003;37(5):278-287
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The performance of nitroglycerin-challenged Tc-99m-MIBI quantitative gated SPECT for the detection of viable myocardium was compared with rest/ 24-hour redistribution Tl-201 SPECT. MATERIALS AND METHODS: In 22 patients with coronary artery disease, rest Tl-201/ dipyridamole stress Tc-99m-MIBI gated/ 24-hour redistribution Tl-201 SPECT were performed, and gated SPECT was repeated on-site after sublingual administration of nitroglycerin (0.6 mg). Follow-up gated SPECT was done 3 months after coronary artery bypass graft surgery. For 20 segments per patient, perfusion at rest and 24-hour redistribution, and wall motion and thickening at baseline and nitroglycerin-challenged state were quantified. Quantitative viability markers were evaluated and compared; (1) rest thallium uptake, (2) thallium uptake on 24-hour redistribution SPECT, (3) systolic wall thickening at baseline, and (4) systolic wall thickening with nitroglycerin-challenge. RESULTS: Among 100 revascularized dysfunctional segments, wall motion improved in 66 segments (66%) on follow-up gated myocardial SPECT after bypass surgery. On receiver operating characteristic (ROC) curve analysis, the sensitivity and specificity of rest and 24-hour delayed redistribution Tl-201 SPECT were 79%, 44% and 82%, 44%, respectively, at the optimal cutoff value of 50% of Tl-201 uptake. The sensitivity and specificity of systolic wall thickening at baseline and nitroglycerin-challenge were 49%, 50% and 64%, 65% at the optimal cutoff value of 15% of systolic wall thickening. Area under the ROC curve of nitroglycerin-challenged systolic wall thickening was significantly larger than that of baseline systolic wall thickening (p=0.004). CONCLUSION: Nitroglycerin-challenged quantitative gated Tc-99m-MIBI SPECT was a useful method for predicting functional recovery of dysfunctional myocardium.
