Preparation and Biodistribution of Re-188-Sulfur Colloid Suspension in Lipiodol.
- Author:
Young Ju KIM
1
;
Jae Min JEONG
;
Seok Ki KIM
;
Miwon SON
;
Dong Soo LEE
;
June Key CHUNG
;
Myung Chul LEE
Author Information
1. Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea. jmjng@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Re-188-Sulfur Colloid;
Lipiodol;
Hepatoma;
Biodistribution
- MeSH:
Animals;
Arteries;
Autoradiography;
Carcinoma, Hepatocellular;
Centrifugation;
Colloids*;
Ethiodized Oil*;
Feasibility Studies;
Heart Ventricles;
Hepatic Artery;
Liver;
Liver Neoplasms;
Lung;
Mice;
Rats;
Veins
- From:Korean Journal of Nuclear Medicine
2003;37(5):301-307
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Lipiodol is used for targeting liver cancers by administrating through the hepatic artery. In the present study, feasibility of Re-188-sulfur colloid suspension in lipiodol as a liver cancer targeting agent was investigated. MATERIALS AND METHODS: Re-188-sulfur colloid was prepared, harvested by centrifugation, washed with organic solvent and then suspended into lipiodol. Biodistribution of Re-188-sulfur colloid in normal saline and its suspension in lipiodol in mice after 1 hr of injection through the tail vein were investigated. Biodistribution and autoradiography of tumor-bearing liver was acquired after 5 min post-injection into left ventricle of the tumor-inoculated rats. RESULTS: After 1 hr of injection with Re-188-sulfur colloid suspensiob in lipiodol through the tail vein in normal mice (n=3), the uptakes in the liver and lung were 5.2+/-0.7 and 91.0+/-1.7% ID/organ, respectively. After 5 min of injection with Re-188-sulfur colloid suspention in lipiodol through the left ventricle in the tumor-inoculated rats (n=4), uptakes in the normal liver, hepatoma, and lung were 0.41+/-0.28, 1.88+/-1.57, and 1.65+/-1.54% ID/organ, respectively. And autoradiography of hepatoma showed increased uptake than normal liver tissues. CONCLUSION: Re-188-sulfur colloid suspension in lipiodol injected through the artery shows higher uptake in the hepatoma than normal liver tissue that indicates the feasibility as a new radiopharmaceutical for therapy of hepatoma.
