Two new abietane diterpenes from Rosmarinus officinalis
10.7501/j.issn.0253-2670.2019.20.001
- Author:
Rui-Ying YUAN
1
Author Information
1. Medical College, Tibet University
- Publication Type:Journal Article
- Keywords:
7-O-isopropyl rosmaquinone;
7-O-isopropyl-epirosmanol;
Abietane diterpenoid;
Cytotoxicity;
Rosmarinus officinalis Linn.
- From:
Chinese Traditional and Herbal Drugs
2019;50(20):4853-4858
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the chemical constituents of aerial part of Rosmarinus officinalis. Methods: Compounds were isolated and purified by repeated column chromatography on silica gel column and Sephadex LH-20 gel column. The structures of the new compounds were elucidated by analysis of their NMR and HRESIMS data. The cytotoxicity of the compounds was evaluated by SRB methods. Results: Ten compounds were obtained and identified as 7-O-isopropyl-epirosmanol (1), 7-O-isopropyl rosmaquinone (2), rosmanol (3), 7-O-methyl-rosmanol (4), epirosmanol (5), 7-methoxy-epirosmanol (6), rosmaquinone B (7), carnosol (8), galdosol (9) and pisiferal (10). Conclusion: Compounds 1 and 2 are new abietane diterpenes named 7-O-isopropyl-epirosmanol (1), 7-O-isopropyl rosmaquinone (2), and showed no cytotoxicity.
