Internet pharmacology analysis of mechanism of Sini Powder in intervening anxiety disorder
10.7501/j.issn.0253-2670.2019.21.004
- Author:
Lei HOU
1
Author Information
1. The Second Hospital of Shandong University
- Publication Type:Journal Article
- Keywords:
Anxiety disorder;
Kaempferol;
Network pharmacology;
Paeoniflorin;
Quercetin;
Sini Powder
- From:
Chinese Traditional and Herbal Drugs
2019;50(21):5154-5161
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the efficacy network and pharmacodynamic mechanism of Sini Powder in the intervention of anxiety disorders. Methods: Using the method of network pharmacology, multiple databases were used to analyze the targets of Sini Powder and anxiety disorders. Cytoscape was used to screen targets and analyze their gene functions and signaling pathways. BioGPS database was used to locate the target organs. Results: The results showed that quercetin, kaempferol, and paeoniflorin acted on SRC, EGFR, PIK 3R1, and other targets, through ERBB2 signaling pathway, EGFRvIII signaling pathway, and VEGFA-VEGFR2 signaling pathway. The results of organ localization showed that the core disease site was liver. Conclusion: By predicting the possible mechanism of Sini Powder in the intervention of anxiety disorder, this study reflects the characteristics of Chinese medicine in the multi-component, multi-target, and multi-channel role, which provides a scientific basis for further elucidating the mechanism of Sini Powder in the intervention of anxiety disorder.
