Research on drug use rules of ancient and modern medical prescriptions for differentiation and treatment of digestive system tumors based on data mining
10.7501/j.issn.0253-2670.2019.22.034
- Author:
Zhuo-Cao QI
1
Author Information
1. Basic Medical College of Nanjing University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Cancer;
Cancer Prescription Daquan;
Data mining;
Digestive system;
Factor analysis
- From:
Chinese Traditional and Herbal Drugs
2019;50(22):5632-5638
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the rule of prescription medication in the treatment of digestive system tumors. All the digestive system cancer prescriptions in Cancer Prescription Daquan were entered into Microsoft Excel 2010, the database was established and the frequency, drug pairs and categories of traditional Chinese medicine were counted. IBM SPSS Modeler 14.1 was used for correlation analysis, and IBM SPSS Statistics 21 was used for clustering and factor analysis. A total of 501 prescriptions for digestive system tumors were studied, involving 651 kinds of Chinese materia medica. Poria, Citri Reticulatae Pericarpium, Aucklandiae Radix, and Angelicae Sinensis Radix were the most frequently used drugs, and Poria-Atractylodis Macrocephalae Rhizoma, Sparganii Rhizoma-Curcumae Rhizoma, Citri Reticulatae Pericarpium-Aucklandiae Radix were the most frequently used drug pairs; Chinese herbal medicine categories of heat-clearing drugs, deficiency-tonifying drugs, blood-activating and stasis-removing drugs were the most frequently used. The highest frequency of Sparganii Rhizoma-Curcumae Rhizoma and Poria-Atractylodis Macrocephalae Rhizoma was found in correlation network diagram; Cluster analysis found 12 Chinese herbal medicine combinations; Six common factors were extracted from the analysis, and the highest loads in sequence were Atractylodis macrocephalae Rhizoma, Sparganii Rhizoma, and Rhei Radix et Rhizoma. The prescriptions of digestive system tumors contained in Cancer Prescription Daquan are based on the core of dispersing symptoms and resolving nodules. Its usually change and use flexibly drugs from three angles of regulating qi, removing dampness, promoting qi and reducing adverse reactions to disperse turbidity, activating blood circulation and benefiting qi, and eliminating blood stasis; clearing away heat, fighting toxins and activating blood circulation to resolve accumulate.
