Membrane permeability evaluation method of oral drugs and their application progress in Chinese materia medica
10.7501/j.issn.0253-2670.2019.22.030
- Author:
Xiao-Lin BI
1
Author Information
1. Nanjing University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Absorption and transport mechanism;
Chinese materia medica;
Effective substance basis;
Membrane permeability;
Oral absorption
- From:
Chinese Traditional and Herbal Drugs
2019;50(22):5591-5596
- CountryChina
- Language:Chinese
-
Abstract:
Chinese materia medica is mostly taken orally. The permeability of a drug’s biofilm (e.g. cell membrane) reflects its ability of absorption and transportation in the body. It is of guiding significance to evaluate the membrane permeability of the active components of Chinese materia medica by using appropriate drug permeation model, so as to clarify, the oral absorption and transport mechanism of active ingredients, pharmacodynamic substance basis and dosage form design. The evaluation method of oral drug membrane permeability, as well as the application of various methods in Chinese medicine was summarized for reference in this review.
