Study on secondary metabolites of endophytic fungus Aspergillus ochraceus from Polygonatum cyrtonema
10.7501/j.issn.0253-2670.2019.22.007
- Author:
Zi-Yang CHENG
1
Author Information
1. College of Chemistry and Chemical Engineering, Huangshan University
- Publication Type:Journal Article
- Keywords:
8-hydroxyketone;
Alternariol;
Aspergillus ochraceus;
Cyclo- (L-Leu-L-Ile);
Endophytic fungi;
Polygonatum cyrtonema Hua.;
Secondary metabolites
- From:
Chinese Traditional and Herbal Drugs
2019;50(22):5424-5428
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the secondary metabolites of Aspergillus ochraceus, an endophytic fungus isolated from Polygonatum Cyrtonema. Methods: Compounds were isolated and purified from the EtOAc extract by using chromatography technology and their structures were established on the basis of comprehensive spectroscopic analysis. Results: A total of 15 compounds were obtained and their structures were elucidated as 6,7-dihydroindolizin-8(5H)-one (1), polygonatine A (2), 8-oxo-5,6,7,8-tetrahydro-3-indolizinyl methyl acetate (3), 8-hydroxyketone (4), cyclo-(L-Leu-L-Ile) (5), alternariol (6), seco- patulolide C (7), n-butyl-β-D-fructopyranoside (8), Nb-acetyltryptamine (9), N-trans-cinnamoyltyramine (10), 5-hydroxy- methylfurfural (11), 5,7-dihydroxy-6,8-dimethyl-3-(4’-hydroxybenzyl) chroman-4-one (12), 5,7-dihydroxy-6-methyl-8- methoxy-3- (4’-hydroxybenzyl) chroman-4-one (13), 25R-3-β-hydroxyspirost-5-en-12-one (14), and 25S-3-β-hydroxyspirost-5-en-12-one (15). Conclusion: All chemical constituents are isolated from A. ochraceus for the first time.
