Phenolic constituents of Pumbago zeylanica and their anti-oxidative effects
10.7501/j.issn.0253-2670.2019.22.006
- Author:
Pei-Hong WANG
1
Author Information
1. Department of Pharmacy, The Second Affiliated Hospital of Fujian Medical University
- Publication Type:Journal Article
- Keywords:
Anti-oxidative effects;
Kaempferol- 3-O-α-L-rhamnoside;
Luteolin-6-C-β- glucopyranoside;
Phenolic compounds;
Plumbago zeylanica L.;
Quercetin;
Quercetin 3-O-β-D-galactoside
- From:
Chinese Traditional and Herbal Drugs
2019;50(22):5419-5423
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the phenolic compounds from Plumbago zeylanica and their anti-oxidant activities. Methods :The phenolic compounds and their analogues were isolated and purified by silica gel column chromatography, semi-preparative HPLC, and HPLC. Their structures were identified by spectroscopy data. The isolated compounds were tested for anti-oxidant activity by ABTS assay. Results: Twelve phenolic compounds were obtained and identified as (±)-5,5’-dimethoxyl ariciresionl 4’-O-β-D-glucopyranoside (1), tracheloside (2), quercetin-3-O-β-D-galactoside (3), quercetin-3-O-β-D-glucopyranoside (4), quercetin (5), quercetin 3-O-α-L-rhamnoside (6), kaempferol-3-O-α-L-rhamnoside (7), apigenin-6-C-β-D-glucopyranoside (8), luteolin 6-C-β- glucopyranoside (9), polybotrin (10), 3-O-(β-D-glucopyranosyl)-1-(3’,5’-dimethoxy-4’-hydroxyphenyl)-1-propanone (11), and (2E,4E,1’R,3’S,5’R,8’S)-dihydrophaseic acid-3’-O-β-D-glucopyranoside (12). The anti-oxidant activity experiment showed that compounds 3-9 displayed significant anti-oxidative activities. Conclusion: All of the twelve phenolic compounds are isolated from this plant for the first time. The isolated flavones 3-9 displayed significant anti-oxidative activities.
