Plasma proteomic study in patients with high altitude pulmonary edema (HAPE)
- Author:
Yong-Jun LUO
1
Author Information
1. Department of High Altitude Disease, College of High Altitude Military Medicine, Third Military Medical University
- Publication Type:Journal Article
- Keywords:
Biological markers;
High altitude pulmonary edema;
Plasma;
Proteomics
- From:
Medical Journal of Chinese People's Liberation Army
2012;37(1):31-33
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the differential expressions of protein in the plasma proteome in patients suffering from high altitude pulmonary edema (HAPE) and their implications. Methods The plasmas of six HAPE patients and six healthy controls were studied. The high-abundant proteins in the plasma were removed. The low-abundant proteins in the plasma/serum were segregated by 2-DE. MALDI-TOF/MS was adopted to measure the peptide fingerprints after the differential protein spots were digested by enzymes. Comparison and analysis were made in the GenBank. Results The immunoglobulin K1 light chain, serum transferrin protein precursor, and α-trypsin inhibitor heavy chain-related protein expressions were upregulated in HAPE patients compared with the control group. However the human fibrin glue coagulation protein 3 was down-regulated. Conclusion The differential expression of the above four proteins in the plasma of HAPE patients may be related to the occurrence of HAPE and can be used as the target point for the prediction of HAPE.
