Influence of CD109 on the clinical pathological manifestations of human cervix squamous cell carcinoma
- Author:
Yan-qing LIU
1
Author Information
1. Department of Pathology
- Publication Type:Journal Article
- Keywords:
Clinical;
Pathology;
Uterine cervical neoplasms
- From:
Medical Journal of Chinese People's Liberation Army
2012;37(10):796-799
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the expression of CD109 and the clinical pathological manifestations of human cervix squamous cell carcinoma. Methods Fourteen pieces of normal cervix tissue, 14 pieces of cervical intraepithelial neoplasia 3 (CIN3) tissue, 12 pieces of primary invasive cervix squamous carcinoma tissue and metastatic lymph-node tissue of cervix squamous cell carcinoma in Cancer Hospital of Tianjin Medical University were collected to conduct immunohistochemical staining for detecting the expression of CD109. The results were further confirmed by Western blotting. The expression of Ki-67 in the aforesaid samples was detected by immunohistochemical staining and the relationship between CD109 and Ki-67 was analyzed. Results The CD109 expression gradually increased with tumor progression. The expression of CD109 were significantly higher in cervix squamous cell carcinoma tissue and metastatic lymph-node tissue than in normal cervix tissue and CIN3 tissue (P<0.05). The Ki-67 expression also increased with tumor progression. The differences in Ki-67 expression among the four groups were statistically significant (P<0.05). CD109 expression was positively correlated with the expression of Ki-67(r=0.953, P<0.01). Conclusions CD109 seems to correlate with the proliferation of cervix squamous carcinoma cell and may play an important role in the development, progression, invasion and metastasis of cervix squamous cell carcinoma.
