Mechanism for esophagus-jejunum stent bypass in the treatment of type 2 diabetes mellitus
- Author:
Suo-lin FU
1
Author Information
1. Clinical Medical Postdoctoral Research Station
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Gastric bypass;
Gastrointestinal hormones;
Type 2
- From:
Medical Journal of Chinese People's Liberation Army
2012;37(9):702-705
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of endoscopic esophagus-jejunum covered stent bypass on the treatment of type 2 diabetes mellitus (T2DM), and analyze the mechanism thereof. Methods Five obese Beagle dog models of T2DM underwent endoscopic esophagus-jejunum covered stent bypass to serve as operation group, and five normal Beagle dogs as control group receive endoscopy and exploratory laparotomy. The T2DM indices of both groups, including fast plasma glucose (FPG) level, fast insulin (FINS) level, intravenous glucose tolerance test-2h plasma glucose (IVGTT-2h PG) and IVGTT-2h FINS, were determined regularly before operation and 4, 8 and 12 weeks after operation. The insulin resistance index (HOMA-IR) and the function of islet β-cell (HOMA-β) were calculated with Homeostasis Model Assessment. The levels of gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1(GLP-1) were also determined. Results Four weeks after operation, FPG, FINS, IVGTT-2h PG, and IVGTT-2h FINS all decreased significantly in operation group (P<0.01), and all these indices reached the levels of control group 12 weeks after operation (P>0.05). The HOMA-IR index declined distinctly and HOMA-β index ascended obviously in operation group 4 weeks after operation (P<0.01), and then recovered to the normal level 12 weeks after operation (P>0.05). The level of GIP lowered significantly (P<0.01), while of GLP-1 was elevated (P<0.05) 4 weeks after operation, and then returned to the normal levels 8 weeks after operation (P>0.05). Conclusion T2DM may be treated with esophagus-jejunum covered stent bypass effectively and safely, and the mechanism thereof might be related to the changes in gastrointestinal hormones.
