The progress of research into interleukin gene polymorphism associated with stroke
- Author:
Chen CHEN
1
Author Information
1. Central Hospital of Taiyuan, Shanxi Medical University
- Publication Type:Journal Article
- Keywords:
Cerebrovascular accident;
Inflammation mediators;
Interleukins;
Polymorphism;
Single nucleotide
- From:
Medical Journal of Chinese People's Liberation Army
2013;38(1):78-81
- CountryChina
- Language:Chinese
-
Abstract:
As a common disease, stroke seriously impairs human health. Interleukin (IL) is an important type of inflammatory mediators, which is involved in the pathogenesis of stroke. With the study of genomics, we discovered that some gene loci of IL were associated with stroke, such as IL-1α-889 C/T, IL-1RN rs380092 and IL-10-1082 G/G. Meanwhile, some gene loci of IL might become independent risk factors of stroke, such as IL-4 C582T and IL4-589C>T. Therefore, the IL gene polymorphism had become a research focus in pathogenesis of stroke. Our paper describes the relationship between IL subtype and its gene polymorphism with stroke. We look forward to provide a useful information for further research.
