Clinical observation on effets of high frequency oscillating ventilation on patients with early acute respiratory distress syndrome
- Author:
Zhi-Gang ZHANG
1
Author Information
1. Department of ICU, First Hospital of Lanzhou University
- Publication Type:Journal Article
- Keywords:
Adult;
High-frequency ventilation;
Respiratory distress syndrome
- From:
Medical Journal of Chinese People's Liberation Army
2013;38(1):58-61
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of high frequency oscillating ventilation (HFOV) on patients with early acute respiratory distress syndrome (ARDS) and its mechanism. Methods Through self controlled study, in 25 patients who met criteria of ARDS, their PaO2/FiO2, Paw, arterial blood pH, PaCO2, Cst, cadiac index (CI), heart rate (HR), central venous pressure (CVP), percentage pulmonary shunt (QS/QT), oxygen index (OI) and incidence rate of ventilator associated lung injury (VALI), ventilator associated pneumonia (VAP) were recorded 1, 3, 5 days before and after HFOV. Results Five days later, X ray examination showed that all of the patients got better. Seven days later, 3 patients died because of original diseases, but their symptoms of ARDS improved. Three days after HFOV treatment, the value of PaO2/FiO2 (172.5±69.8) and Cst (63.4±10.5) increased compared with baseline (95.5±29.5, 31.5±4.5, P<0.05, P<0.01), while OI(12.8±8.1) and QS/QT (0.28±0.11) decreased compared with baseline (25.4±13.5, 0.46±0.12, P<0.05). There were not significant difference in Paw, PaCO2, arterial blood pH, CVP, HR, CI and related parameters at different time point after treatment (P>0.05). Conclusion HFOV can improve oxygenation index and pulmonary complications of patients with early ARDS.
