Progress of cardioprotective effects of high density lipoprotein: Function and mechanism
10.11855/j.issn.0577-7402.2014.11.13
- Author:
Hai-Ge SUN
1
Author Information
1. Department of Cardiology, Nanfang Hospital, Southern Medical University
- Publication Type:Journal Article
- Keywords:
Atherosclerosis;
HDL;
Hematopoietic stem cells;
Immunity;
Inflammation;
Lipoprotein
- From:
Medical Journal of Chinese People's Liberation Army
2014;39(11):908-911
- CountryChina
- Language:Chinese
-
Abstract:
The high density lipoprotein (HDL) in human plasma is a heterogeneous lipoprotein consisting of roughly equal contents of lipid and protein in roughly equal content, and it consists of several subtypes. HDL possesses several well-documented functions, including anti-atherosclerosis by promoting reverse cholesterol transport, inhibiting the oxidative modification of low density lipoproteins (LDLs), inhibiting vascular inflammation, preventing thrombosis and apoptosis, and promoting endothelial repair. Recently, more cardiovascular protective functions of HDL have been found, mainly including the ability of suppressing immune inflammatory reaction, inhibiting the proliferation of hematopoietic stem cells, and regulating the plasma glucose level. It is of great importance to understand how different HDL subtypes contribute to the potentially cardioprotective functions.
