The effect of soy isoflavones on early high altitude polycythemia: A multicenter clinical study of 80 cases
10.11855/j.issn.0577-7402.2014.11.12
- Author:
Qian-Jin YU
1
Author Information
1. Haematology Research Center of PLA, Xinqiao Hospital, Third Military Medical University
- Publication Type:Journal Article
- Keywords:
Efficacy;
High altitude polycythemia;
Oxygen;
Soy isoflavones
- From:
Medical Journal of Chinese People's Liberation Army
2014;39(11):902-907
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of oxygen inhalation combined with oral administration of soy isoflavones on people who migrated from plains to high altitude area suffering from polycythemia. Methods Eighty young men, who migrated to the area of altitude of 3500~5300m for more than ten months, and their hemoglobin (HGB) level was verified in the range of 190g/L≤HGB <210g/L, which was confirmed by blood routine examination for three times, were randomly divided into 2 groups: oxygen group (n=37) and oxygen plus soy isoflavones group (n=37). For the former, the subjects were given low flow oxygen inhalation (1-2L/min) for 1.5 hours, 2-4 times per day; for the latter, the subjects were given low flow oxygen therapy (same as the former) combined with oral administration of 40mg soy isoflavones per day. After 12 weeks, all the subjects were rechecked with blood routine examination and the clinical symptoms of chronic mountain sickness (CMS) score, to evaluate the improvement in red blood cell (RBC), hemoglobin (HGB), hematocrit (HCT), and the clinical symptoms. Results After 12 weeks of follow-up, the value of HGB in oxygen plus soy isoflavones group was lowered by 8.76 ± 5.15g/L, while in oxygen group it was lowered by 4.16 ± 5.33g/L, and the magnitude of lowering was significantly different between the two groups (P<0.05). The degree of improvement of clinical symptoms after the intervention was observed in the two groups, and it was found that obvious improvement was observed in the oxygen plus soy isoflavones group (P<0.05), but no obvious improvement was observed in oxygen group (P>0.05). Multiple linear regression analysis revealed that the affecting factors of HGB that the change in HGB values was significantly associated with test grouping. In addition, there were no obvious side effects and changes in BP, ECG, chest X-ray, liver and kidney functions before and after soy isoflavones intake. Conclusion In high-altitude area, oxygen and oral administration of soy isoflavones are safe and more effective measure in the early prevention of high altitude polycythemia.
