Analysis of clinical characteristics and prognosis of peripheral T-cell lymphoma (PTCL) in elderly patients
10.11855/j.issn.0577-7402.2014.11.10
- Author:
Jin WANG
1
Author Information
1. Department of Hematology, Changhai Hospital
- Publication Type:Journal Article
- Keywords:
Aged;
Peripheral T-cell lymphoma;
Prognosis
- From:
Medical Journal of Chinese People's Liberation Army
2014;39(11):893-897
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics and prognostic factors of peripheral T-cell lymphoma (PTCL) in elderly patients. Methods The complete clinical data of 59 patients out of 63 cases of elderly PTCL patients, who were admitted to the Hematology Department of Shanghai Changhai Hospital from January 2005 to May 2013, were collected, and the clinical features of these patients, who were followed-up for 33 months (1-99 months), were retrospectively analyzed. SPSS 22.0 was employed for the statistical analysis, survival analysis was performed by Kaplan-Meier method, and then the Log-rank test was done, the survival rate was calculated with life table method, and the COX proportional hazard model was used to perform multivariate analysis. Results The median survival time was 13 months, and the expected 1-year, 2-year and 3-year overall survival rate (OS) was 47%, 41% and 30%, respectively. Univariate analysis showed that the serum lactate dehydrogenase (LDH, P<0.001), serum ß2-microglobulin (P<0.001), PS score (P<0.001), IPI points (P<0.001), bone marrow involvement (P=0.011), extranodal involved sites (>1) (P<0.001), Ki-67 percentage (P<0.001), as well as the efficacy and course of chemotherapy (P<0.001) were all the prognostic indicators affecting the survival time in this cohort of elderly patients. Multivariate analysis indicated that PS score, IPI points, extranodal involved sites (>1), the efficacy and course of chemotherapy were the independent prognostic indicators affecting the survival time (P<0.05) Conclusions PS score, IPI points and extranodal involved sites (>1) are of great significance for predicting the prognosis in elderly PTCL patients. The completion of a certain intensity of chemotherapy to achieve remission is an important measure to prolong survival time in elderly PTCL patients.
