Genetic polymorphism of 30 autosomal InDel loci in Chinese uygur population residing in Xinjiang
10.11855/j.issn.0577-7402.2014.10.10
- Author:
Ru-Feng BAI
1
Author Information
1. Key Laboratory of Evidence Science of Ministry of Education, China University of Political Science and Law
- Publication Type:Journal Article
- Keywords:
Genetics population;
Insertion/deletion polymorphisms (InDel);
Uygur nationality
- From:
Medical Journal of Chinese People's Liberation Army
2014;39(10):808-814
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the genetic data of 30 insertion deletion polymorphism (InDel) loci included in Investigator® DIPplex in Uygur population from Xinjiang, and evaluate its application in forensic medicine. Methods Allele frequencies, population genetics parameters of the 30 InDels were determined in 223 unrelated Uygur individuals with Investigator® DIPplex, and they were statistically analyzed and compared with available data of other populations of different races from different regions. Results After Bonferroni's correction, there were no significant departure from Hardy-Weinberg equilibrium or linkage disequilibrium between the loci. The average heterozygosity (Ho) was 0.468 6, the mean discrimination power (DP) was 0.609 5, and the total probability of discrimination power (TDP) reached 0.999 999 999 995. The cumulative probability of exclusion was 0.995 478 in trio cases (CPEtrio) and 0.972 007 in duo cases (CPEduo). The genetic distance between Uygur and Kazakh was closer than those between Uygur and other populations, such as African American. Conclusion Multiplex detection of the 30 InDel loci revealed a moderately high polymorphic genetic distribution in Chinese Uygur population residing in Xinjiang, demonstrating that the Investigator® DIPplex kit can be used as a supplementary tool for human identity tests, especially in challenging DNA cases.
