Diagnostic value of 18F-FDG uptake by spleen in acute radiation disease
10.11855/j.issn.0577-7402.2015.07.08
- Author:
Shao-Jie WU
1
Author Information
1. Department of Hematology, Zhujiang Hospital, Southern Medical University
- Publication Type:Journal Article
- Keywords:
Acute radiation syndrome;
Fluorodeoxyglucose F18;
Positron-emission tomography and computed tomography;
Radiation dosage;
Spleen
- From:
Medical Journal of Chinese People's Liberation Army
2015;40(7):554-558
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether 18F-FDG uptake can be applied in dosimetry to facilitate a rapid and accurate evaluation of individual radiation dosage after a nuclear accident. Methods Forty-eight Tibetan minipigs were randomly assigned into 6 groups, i.e., 0, 1, 2, 5, 8 and 11Gy groups. Animals in all except 0Gy group received total body irradiation (TBI) with a 8MV X centrifugal linear accelerator, and 18F-FDG combined positron-emission tomography and computed tomography (PET/CT) were carried out before TBI, and also at 6, 24 and 72h after receiving TBI in different doses ranging from 1 to 11Gy. Spleen tissues and blood samples were collected for histological examination, apoptosis, and routine blood analysis. Results Mean standardized uptake values (SUVs) of the spleen showed significant differences between experimental groups and control group. The spleen SUVs at 6h post-irradiation showed significant correlation with radiation dose; Spearman's correlation coefficient was 0.95(P<0.01). Histopathological observations showed that the degree of splenic damage was proportional to the radiation dose. Moreover, flow cytometry revealed that apoptosis was one of the major forms of splenic lymphocyte death. Conclusion In the Tibetan minipig model, it was shown that radiation doses bear a close relationship with the 18F-FDG uptake of spleen. This finding suggests that 18F-FDG PET/CT may be useful for the rapid detection of individual radiation dosage after acute radiation disease (ARD).
