Interactions Between Innate Immunity Genes and Early-Life Risk Factors in Allergic Rhinitis.
10.4168/aair.2015.7.3.241
- Author:
Ju Hee SEO
1
;
Hyung Young KIM
;
Young Ho JUNG
;
Eun LEE
;
Song I YANG
;
Ho Sung YU
;
Young Joon KIM
;
Mi Jin KANG
;
Ha Jung KIM
;
Kang Seo PARK
;
Ji Won KWON
;
Byung Ju KIM
;
Hyo Bin KIM
;
Eun Jin KIM
;
Joo Shil LEE
;
So Yeon LEE
;
Soo Jong HONG
Author Information
1. Department of Pediatrics, Korean Cancer Center Hospital, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Obstetric delivery;
infant food;
antibiotics;
gene-environment interaction, allergic rhinitis
- MeSH:
Anti-Bacterial Agents;
Child;
Chronic Disease;
Cross-Sectional Studies;
Delivery, Obstetric;
Feeding Methods;
Female;
Gene-Environment Interaction;
Genotype;
Humans;
Immunity, Innate*;
Infant Food;
Rhinitis*;
Risk Factors*;
Skin;
Surveys and Questionnaires
- From:Allergy, Asthma & Immunology Research
2015;7(3):241-248
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Allergic rhinitis (AR) is a common chronic disease. Many factors could affect the development of AR. We investigated early-life factors, such as delivery mode, feeding method, and use of antibiotics during infancy, which could affect the development of AR. In addition, how interactions between these factors and innate gene polymorphisms influence the development of AR was investigated. METHODS: A cross-sectional study of 1,828 children aged 9-12 years was conducted. Three early-life factors and AR were assessed by a questionnaire. Skin prick tests were done. Polymorphisms of TLR4 (rs1927911) and CD14 (rs2569190) were genotyped. RESULTS: Use of antibiotics during infancy increased the risk of AR (aOR [95% CI] 1.511 [1.222-2.037]) and atopic AR (aOR [95% CI], 1.565 [1.078-2.272]). There were synergistic interactions between caesarean delivery, formula feeding, and use of antibiotics in the rate of atopic AR (aOR [95% CI], 3.038 [1.256-7.347]). Additional analyses revealed that the risk for the development of AR or atopic AR subjects with the TLR4 CC genotype were highest when all the 3 early-life factors were present (aOR [95% CI], 5.127 [1.265-20.780] for AR; 6.078 [1.499-24.649] for atopic AR). In addition, the risk for the development of AR or atopic AR in subjects with the CD14 TT genotype were highest when all the 3 early-life factors were present (aOR [95% CI], 5.960 [1.421-15.002] for AR; 6.714 [1.440-31.312] for atopic AR). CONCLUSIONS: Delivery mode, feeding method, and use of antibiotics during infancy appeared to have synergistic interactions in the development of AR. Gene-environment interactions between polymorphism of innate genes and early- life risk factors might affect the development of AR.
