Analysis on immunological function recovery and its influential factors in HIV/AIDS patients receiving highly active antiretroviral therapy for two years in Xi’an city
10.11855/j.issn.0577-7402.2016.12.10
- Author:
Ya-Lan ZHANG
1
Author Information
1. Department of HIV/AIDS Prevention and Control, Xi’an City Center for Disease Control and Prevention
- Publication Type:Journal Article
- Keywords:
Acquired immunodeficiency syndrome;
Antiretroviral therapy;
Highly active;
T-lymphocytes
- From:
Medical Journal of Chinese People's Liberation Army
2016;41(12):1020-1024
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the dynamic variation of CD4+ T-lymphocyte counts and influential factors in HIV/AIDS patients receiving highly active antiretroviral therapy (HAART) for two years in Xi’an City. Methods HIV/AIDS patients who were diagnosed in 2013 and received antiviral treatment within one month after final diagnosis. Their CD4+ T-lymphocytes counts at baseline, 3, 6, 12 and 24 months after the initiation of HAART were recorded. By using the general linear model repeated-measures ANOVA, CD4+ T-lymphocytes dynamic variations and influential factors were described and analyzed. Results The average CD4+ cell counts at baseline, and 3, 6, 12 and 24 months after treatment were 312.4±211.4, 360.2±265.8, 379.7±203.7, 435.3±242.0 and 519.5±276.0 cells/μl, respectively. CD4+ T-lymphocytes counts increased over time after treatment (F=27.51, P<0.01). But there were still 13.8%(25/181) cases of immunological failure during the 24-month treatment. The composition of the case of immunological failure in baseline CD4+ T-lymphocytes count <100 cells/μl was 27.0%(10/37). CD4+ T-lymphocyte counts increased slowly, body mass index (BMI)<18.5kg/m2 compared with 18.5kg/m2≤BMI≤23.9kg/m2 and BMI≥24.0kg/m2 (P<0.01). There was a statistically significant difference in the dynamic trend of CD4+ T-lymphocytes after treatment between the co-infections group with HBV/HCV and without co-infection group (F=4.28, P<0.05). Conclusions CD4+ T-lymphocytes count in patients with HIV/AIDS receiving HAART in Xi’an City could be affected by various factors, the low baseline CD4+ T-lymphocytes count, BMI<18.5kg/m2 and HBV/HCV infections will influence recovery of immune function after HAART in HIV/AIDS patients.
