Immunologic Evaluation of Patients with Cefotetan-Induced Anaphylaxis.
10.4168/aair.2015.7.3.301
- Author:
Young Hee NAM
1
;
Eui Kyung HWANG
;
Ga Young BAN
;
Hyun Jung JIN
;
Hye Soo YOO
;
Yoo Seob SHIN
;
Young Min YE
;
Dong Ho NAHM
;
Hae Sim PARK
;
Soo Keol LEE
Author Information
1. Department of Internal Medicine, College of Medicine, Dong-A University, Busan, Korea. skleeai@dau.ac.kr
- Publication Type:Case Report
- Keywords:
Anaphylaxis;
cefotetan;
specific IgE;
specific IgG4
- MeSH:
Aged;
Anaphylaxis*;
Bacteria;
Basophils;
Cefotetan;
Dyspnea;
Enzyme-Linked Immunosorbent Assay;
Female;
Humans;
Hypersensitivity;
Hypotension;
Immunoglobulin E;
Immunoglobulin G;
Middle Aged;
Serum Albumin;
Thorax;
Up-Regulation
- From:Allergy, Asthma & Immunology Research
2015;7(3):301-303
- CountryRepublic of Korea
- Language:English
-
Abstract:
Cefotetan is a commonly prescribed second-generation cephalosporin that acts against a wide range of bacteria. However, cefotetan-induced hypersensitivity has rarely been reported. We report 2 cases of cefotetan-induced anaphylaxis with immunologic evaluation. The first case was a 70-year-old asthmatic woman who had dyspnea and hypotension during administration of cefotetan, in which high serum-specific IgE to cefotetan-human serum albumin (HSA) conjugate was detected by enzyme-linked immunosorbent assay. The second case was a 63-year-old asthmatic woman who complained of chest tightness and dyspnea during cefotetan infusion, in which high serum-specific IgG1 and IgG4 with no serum specific IgE to cefotetan-HSA conjugate was detected. The basophil activation test using basophils from the patient showed a significant up-regulation of CD63 with the addition of anti-IgG4 antibody compared with that in non-atopic healthy controls. In conclusion, cefotetan can induce anaphylaxis, which may involve both IgE- and IgG4-mediated responses in the pathogenic mechanism.
