Mechanism of blood-brain barrier impairment after mild traumatic brain injury caused by blast shock waves and its relationship with delayed nerve dysfunction
10.11855/j.issn.0577-7402.2016.05.15
- Author:
Zhao-Xi XU
1
Author Information
1. Department of Neurosurgery, Wuhan General Hospital of Guangzhou Command
- Publication Type:Journal Article
- Keywords:
Blast injuries;
Blood-brain barrier;
Craniocerebral trauma;
Delayed neurological deficits;
Shock wave
- From:
Medical Journal of Chinese People's Liberation Army
2016;41(5):425-429
- CountryChina
- Language:Chinese
-
Abstract:
Mild traumatic brain injury (mTBI) caused by blast shock waves (BSWs) is one of the most common injuries among soldiers in the war. Such mTBI can also happen in civilians if exposed to shock waves of accidental explosion disasters, bomb attacks by terrorists and so on. This injury often results in cognitive problems, memory dysfunction and emotional disorder, and these neurological deficits are closely related to the dysfunction or disruption of the blood-brain barrier (BBB). The present paper discusses mainly the relationship between dysfunction or disruption of BBB and inflammatory reaction in mild brain injury associated with explosive shock wave and effects of early intervention of oxidative stress injury, repairing the BBB and blocking inflammation on relieving delayed neurological deficits.
