Risk factors for incidence of white matter lesion in patients with ischemic cerebrovascular diseases: A retrospective analysis of 417 cases
10.11855/j.issn.0577-7402.2016.05.10
- Author:
Wen-Lei SHI
1
Author Information
1. Department of Neurology, General Hospital of Beijing Command
- Publication Type:Journal Article
- Keywords:
Risk factors;
Small vessel disease;
White matter lesion
- From:
Medical Journal of Chinese People's Liberation Army
2016;41(5):401-406
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the risk factors of white matter lesions (WMLs), especially on the correlation of WMLs incidence with those well known risk factors for cerebrovascular disease (hypertension, hyperglycemia, hyperlipemia and smoking). Methods Four hundred and seventeen consecutive inpatients in Neurology Department of our hospital were enrolled who had undergone brain MRI. Detailed clinical history, relevant data and the Fazekas scores of WMLs were collected. Logistic regression was used to analyze the independent risk factors. Results Age (P=0.000), homocysteine level (P=0.010), grade of hypertension (P=0.007), patients with diabetes for less than 10 years (P=0.033) and smoking more than 40 years (P=0.003) were correlated with WMLs. In the group of patients with ischemic cerebrovascular disease, the independent risk factors of WMLs are Age (P=0.006), smoking (P=0.000) and grade of hypertension (P=0.028). Conclusions Age, homocysteine level and grade of hypertension are independently correlated with WMLs. Age, smoking and grade of hypertension are the independent risk factors for the patients with WMLs and ischemic cerebrovascular disease.
