Maternal TSH level and TPOAb status before 20 weeks and their relationship to adverse pregnancy outcomes
10.11855/j.issn.0577-7402.2019.10.11
- VernacularTitle: 妊娠20周前TSH水平及TPOAb状态与妊娠结局的关系
- Author:
Hu-ying ZHAO
1
Author Information
1. Department of Gynecology and Obstetrics, Zhujiang Hospital of Southern Medical University
- Publication Type:Journal Article
- Keywords:
Pregnancy complications;
Pregnancy outcomes;
Thyroid peroxidase antibody;
Thyroid stimulating hormone
- From:
Medical Journal of Chinese People's Liberation Army
2019;44(10):871-875
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of TSH levels and TPOAb status before 20 weeks gestation with adverse pregnancy outcomes. Methods A total of 2885 pregnant women who underwent regular prenatal examination in Zhujiang Hospital of Southern Medical University during April 1, 2017 to October 31, 2018 were retrospectively analyzed. According to the TSH level before 20 weeks of gestation, they were classified into normal TSH (0.1 mU/L≤TSH<2.5 mU/L), normal high TSH (2.5 mU/L≤TSH<4.0 mU/L), subclinical hypothyroid (4.0 mU/L0.05). In multi-factor logistic regression analysis results show that the risk of a preterm birth in group D, group E, group F were higher than that in control group, the risk of gestational diabetes in group F was higher than that in control group (OR>1, P<0.05). Conclusions Women with subclinical hypothyroidism and high TSH before 20 weeks of gestation combined with TPOAb positive have an increased risk of preterm labor, and women with subclinical hypothyroidism combined with TPOAb positive have an increased risk of gestational diabetes. Therefore, clinical attention should be paid to such women, and the management of gestation should be strengthened to prevent the occurrence of mid-to-late complications.
