Progress in the study for immune escape-related mutation in the S region of hepatitis B virus
10.11855/j.issn.0577-7402.2019.02.14
- Author:
Bi-Xia HUANG
1
Author Information
1. Institute of Aging Research/Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University
- Publication Type:Journal Article
- Keywords:
Clinical presentations;
Hepatitis B virus;
Immune escape;
Mutations;
S gene
- From:
Medical Journal of Chinese People's Liberation Army
2019;44(2):171-175
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B virus (HBV) infection could lead to different clinical presentations and disease progresses, including acute and chronic hepatitis B, liver cirrhosis, hepatocellular carcinoma, and occult HBV infection, in which the interaction between virus and host plays an important role. Because HBV reverse transcriptase is lack of correction function, HBV is prone to generate mutations under the pressure of host immune response and antiviral drug treatment. Some mutations in the HBV S gene-encoding region can significantly attenuate antibody immune response against HBV and therefore affect clinical presentations and disease progression. Such mutations are termed immune escape-related mutations. In this paper, we mainly review the structure and functional characteristics of HBV S gene, the causes and forms of the immune escape-related mutation, its influence on clinical presentations and antiviral treatment response, as well as clinical detection methods.
