Advances on the role of miRNAs in the formation of alcoholic fatty liver
10.11855/j.issn.0577-7402.2020.03.18
- Author:
Zhi-Hua ZUO
1
Author Information
1. Department of Clinical Laboratory, Affiliated Hospital of Southwest Medical University
- Publication Type:Journal Article
- Keywords:
Alcoholic;
Fatty liver;
Inflammatory reaction;
Lipid metabolism;
MicroRNAs
- From:
Medical Journal of Chinese People's Liberation Army
2020;45(3):330-334
- CountryChina
- Language:Chinese
-
Abstract:
Alcoholic fatty liver disease (AFLD) is a pathological change of liver steatosis caused by long-term heavy alcohol consumption. The mechanism of AFLD formation mainly includes abnormal lipid metabolism, immune-inflammatory reaction, intestinal flora imbalance, alcohol metabolism enzyme disorder and so on. In recent years, numerous studies have confirmed that microRNA (miRNA) plays an important role in diagnosis and treatment of many diseases, the molecular regulatory mechanism of miRNAs involved in AFLD formation has also become a research focus. The majority of studies have explored the role of miRNAs in AFLD formation by exploring the targeting role of miRNAs of key genes in the formation pathway of AFLD, and establishing an expression network with genes that promote or inhibit the expression of downstream genes of this signaling pathway. In present paper, the important miRNAs in the formation pathway of AFLD and their regulatory mechanisms in AFLD are reviewed, so as to provide theoretical basis for further understanding the function of miRNAs and its relevant mechanisms in AFLD.
