Research progress on neuroimmune in allergy diseases
10.11855/j.issn.0577-7402.2020.02.07
- Author:
Jing-Yuan CHEN
1
Author Information
1. Department of Otolaryngology, First Affiliated Hospital of Sun Yat-sen University
- Publication Type:Journal Article
- Keywords:
Allergic diseases;
Mechanism;
Neuroimmunomodulation
- From:
Medical Journal of Chinese People's Liberation Army
2020;45(2):150-157
- CountryChina
- Language:Chinese
-
Abstract:
Recent studies have revealed that the interactions of nervous and immune system play a role in the advancement of allergy diseases. Allergy diseases are the consequence of an aberrant response from the immune system to foreign substances and harmful stimuli, have high incidence and the related allergic symptoms seriously affect the patient's quality of life. Specific immune mediator receptors [such as type 1 histamine receptors (H1R), protease activating receptor 2 (PAR-2), tropomyosin receptor kinase A (TrkA)] may be expressed on the surface of neurons and nerve fibers of the nervous system, while neuropeptide receptors [such as neurokinin receptor-1 (NK-1R), vasoactive intestinal peptide receptor (VPAC)] and neurotransmitter receptors [such as α7 acetylcholine nicotinoid-like receptor (α7nAChR), Beta 2 adrenergic receptor (β2AR)] may also be expressed on the immune cell membrane in the immune system. Therefore, esthesioneure can be activated by inflammatory mediators secreted by immune cells to conduct sensation and release neuropeptides and neurotransmitters, while the function of immune cells can be regulated by neuropeptides and neurotransmitters from the nervous system. Further understanding the role of neuroimmune in allergic diseases may provide guidance for the treatment of allergic diseases.
