Research status and progress of laboratory indexes related to neuromyelitis optica spectrum disorders
10.11855/j.issn.0577-7402.2020.05.19
- Author:
Ya-Lan ZHANG
1
Author Information
1. Department of Neurology, Second Hospital of Lanzhou University
- Publication Type:Journal Article
- Keywords:
Aquaporin 4-immunoglobulin G;
Laboratory indexes;
Neuromyelitis optica spectrum disorders (NMOSD)
- From:
Medical Journal of Chinese People's Liberation Army
2020;45(5):573-578
- CountryChina
- Language:Chinese
-
Abstract:
Neuromyelitis optica spectrum disorders (NMOSD) is a group of inflammatory demyelinating diseases of the central nervous system characterized by recurrent optic neuritis or long-segmental myelitis, with high recurrence and disability. The discovery of aquaporin 4-immunoglobulin G (AQP4-IgG) distinguished the disease from multiple sclerosis (MS) and became an independent disease. T cells, B cells and complement system were involved in NMOSD pathogenesis. The levels changed of many cytokines and complements components in NMOSD patients' serum and cerebrospinal fluid, and the levels of other related laboratory indexes such as serum uric acid (UA) and thyroid hormone has also changed dynamically. The research status and progress of some laboratory-related indexes other than AQP4-IgG for NMOSD patients were reviewed in present paper, in order to provide new ideas for clinical diagnosis and prognosis evaluation of NMOSD, and reduce the rates of missed diagnosis and misdiagnosis.
