Research progress on lipodermatosclerosis
10.11855/j.issn.0577-7402.2020.07.16
- VernacularTitle: 脂质硬皮症研究进展
- Author:
Meng-Meng DU
1
Author Information
1. First Clinical Medical College, Shandong University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Fibrosis;
Lipodermatosclerosis;
Transforming growth factor-β1
- From:
Medical Journal of Chinese People's Liberation Army
2020;45(7):767-771
- CountryChina
- Language:Chinese
-
Abstract:
Lipodermatosclerosis (LDS) is a serious skin change associated with the progression of chronic venous insufficiency (CVI) of the lower extremities, and can be clinically divided into acute phase, subacute phase and chronic phase. The disease is common in middle-aged women, prone to occur in the lower leg 1/3, clinical manifestations of the skin flake erythema, induration, pigmentation, skin rough and thickening. The patients often suffer from secondary infection after scratching due to pruritus. The severe ones can form refractory ulcer or even cause skin necrosis, and may be canceration. At present, domestic reports on LDS are less, the clinical manifestations, etiology, pathogenesis and treatment of the LDS are reviewed in present paper, in order to strengthen the understanding of LDS and provide the evidence for clinical diagnosis and treatment of LDS.
