Clinical value of thrombomodulin combined with thrombin-antithrombin complex for judging prognosis for sepsis
10.11855/j.issn.0577-7402.2020.07.12
- VernacularTitle: 血栓调节蛋白联合凝血酶-抗凝血酶复合物判断脓毒症预后的临床价值
- Author:
Lin-Cui ZHONG
1
Author Information
1. Intensive Care Unit, 908th Hospital of Chinese PLA Logistical Support Force
- Publication Type:Journal Article
- Keywords:
Prognosis;
Sepsis;
Thrombin-antithrombin complex;
[Key wards] thrombomodulin
- From:
Medical Journal of Chinese People's Liberation Army
2020;45(7):746-750
- CountryChina
- Language:Chinese
-
Abstract:
[Abstract] Objective To determine the prognostic value of thrombomodulin (TM) combined with thrombin-antithrombin complex (TAT) in patients with sepsis. Methods A retrospective analysis of the clinical data from 80 patients with sepsis who met the inclusion and exclusion criteria admitted to the 908th Hospital of Chinese PLA Logistical Support Force from May 2018 to July 2019. The conventional coagulation tests, thromboelastographic (TEG) parameters, TM, TAT, α2-plasmin inhibitor-plasmin complex (PIC, namely plasmin/alpha 2-antiplasmin complex, PAP) and tissue plasminogen activator-inhibitor-1 complex (t-PAIC) were collected within 2 hours at admission. According to the prognosis of 90 days, the patients were divided into survival group and death group and statistical analysis were performed. Results Compared with TM [11.7(8.8, 15.9) TU/ml] and TAT [11.3(7.0, 20.5) ng/ml] in the survival group, TM [20.2(14.1, 23.8) TU/ml] and TAT [17.7(11.8, 54.6) ng/ml] were significantly increased in the death group (P<0.05). The area under curves (AUC) of TM and TAT judging the prognosis of patients with sepsis were 0.74 and 0.67, respectively. The mortality of patients with sepsis was significantly increased when TM>16.95 TU/ml combined with TAT>10.55 ng/ml. Conclusion TM combined with TAT can effectively judge the prognosis of sepsis patients and early identify sepsis related coagulation disorders.
