Research progress of the effect of cell-specific mineralocorticoid receptor on blood pressure regulation
10.11855/j.issn.0577-7402.2020.10.15
- VernacularTitle: 细胞特异性盐皮质激素受体对血压的调节作用研究进展
- Author:
Qian-Yu MA
1
Author Information
1. First Clinical Medical College of Lanzhou University
- Publication Type:Journal Article
- Keywords:
Action mechanism;
Aging;
Cell specificity;
Hypertension;
Mineralocorticoid;
Receptors
- From:
Medical Journal of Chinese People's Liberation Army
2020;45(10):1105-1108
- CountryChina
- Language:Chinese
-
Abstract:
The extrarenal effects of mineralocorticoid receptor (MR) activation are closely related to the regulation of blood pressure. The activation ability of MR varied with age and gender in blood pressure regulation. MR of different types of cells play an important role in the pathogenesis of hypertension by increasing the expressions of osteogenic transcription factors, epithelial sodium channels, fibrotic substances and fibrogenic factors, change of vascular L-type calcium channels, aggravation of inflammation and oxidative stress, etc., leading to arterial elasticity weakened, myocardial fibrosis, and water sodium retention. Cell-specific MR block provides a theoretical basis for the development of targeted drugs for treatment of hypertension in the future. The effect of cell-specific MR on the regulation of blood pressure has been reviewed in present paper.
