Research progress of effect and mechanism of PGC-1α in cardiovascular diseases
10.11855/j.issn.0577-7402.2020.10.10
- VernacularTitle: PGC-1α在心血管疾病中的作用及可能机制研究进展
- Author:
Chuan-Bin LIU
1
Author Information
1. Medical School of Chinese PLA
- Publication Type:Journal Article
- Keywords:
Cardiovascular diseases;
Mitochondria;
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- From:
Medical Journal of Chinese People's Liberation Army
2020;45(10):1077-1080
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular disease is currently the number one killer of human health. Studies have shown that peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is a key factor in physiological processes such as energy metabolism and oxidative stress, which also involved in regulating mitochondrial biosynthesis. PGC-1α is closely related to the occurrence and development of atherosclerosis, coronary heart disease, atrial fibrillation, cardiomyopathy, myocardial hypertrophy, heart failure and other cardiovascular diseases. This article briefly describes the research progress of PGC-1α in cardiovascular diseases.
