Research progress on the relationship of the genetic polymorphism of maternal immune system and blood system to the recurrent spontaneous abortion

VernacularTitle: 母体免疫系统及血液系统基因多态性与复发性自发流产相关性的研究进展
Author: Wan-Sheng ZHANG ¹
Author Information

1. Center for Reproductive Medicine, Jilin Medical College
Publication Type:Journal Article
Keywords: Blood system; Gene polymorphism; Immune system; Recurrent spontaneous abortion
From: Medical Journal of Chinese People's Liberation Army 2020;45(11):1190-1195
CountryChina
Language:Chinese
Abstract: Recurrent spontaneous abortion (RSA) is an important disease affecting female reproductive health, with an incidence of 1%-5%. The causes of RSA are complex, among which genetic factor is one of the common causes. A large number of studies in recent years have shown that RSA is closely related to the polymorphism of related genes. Normal fetal development requires the successful implantation of embryos and the maintenance of pregnancy, in which the maternal immune system and blood system play an important regulatory role. Therefore, the present paper summarized the relationship of the genetic polymorphism of maternal immune system and blood system to RSA, aiming to elucidate the pathogenesis of RSA at the gene level and provide accurate and feasible guidance for clinical prevention and treatment of RSA.