Diagnosis and therapy of chest primitive neuroectodermal tumor (4 cases report)
- Author:
Bo DENG
1
Author Information
1. Chest Surgery Center of PLA
- Publication Type:Journal Article
- Keywords:
Diagnosis;
Differential;
Prognosis;
Thoracic neoplasms
- From:
Tumor
2007;27(4):319-321
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To discuss the clinical and pathological features, diagnostic standards, therapy and prognosis of chest primitive neuroectodermal tumor (PNET) and to improve diagnostic and therapeutic levels. Methods: Clinical data of four cases of PNET were analyzed retrospectively. Of the 3 cases of mediastial PNET, 2 cases with superior vena cava invasion received partial resection surgery and one case received thoracoscopy-guided mediastinal node biopsy. The 4th case with right lung PNET had supraclavicular node biopsy. Results: All of the four cases were diagnosed as PNET by pathologic and imnmohistochemical examination. Two cases did not receive any therapy, one case received systemic chemotherapy, and one case received local radiotherapy. The life span of the 2 cases who did not receive any therapy was 6 and 7 months, respectively. The life span of the patient who received systemic chemotherapy was 12 months. The patient who received local radiotherapy had survived for 4 months till August of 2006. Conclusion: Chest PNET can occur in every age. Lymph node metastasis may happen when the primary lesion is very small. Misdiagnose rate is very high and final diagnosis depended on pathological plus immunohistochemical examination. Because of the higher malignancy, rapid local invasion and distant metastasis, the resection rate of chest PNET is low and the prognosis is poor. So it is necessary to find a more effective method for treatment of PNET.
