Relationship between the serum levels of cytokines and acute graft-versus-host disease
- Author:
Rong-Li ZHANG
1
Author Information
1. Institute of Hematology and Blood Diseases Hospital
- Publication Type:Journal Article
- Keywords:
Cytokine;
Graft versus host disease;
Hematopoietic stem cell transplantation
- From:
Tumor
2007;27(5):409-411
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the relationship between the serum levels of cytokines and acute graft-versus-host disease (aGVHD) in allogeneic hematopoietic stem cell transplantation. Methods: The serum levels of interleukin-1 (IL-1), interleukin-2 (IL-2), interleukin-4 (IL4), and tumor necrosis factor (TNF ) of 59 patients were determined by radioinummoassay at consecutive time points. The relationship between the serum levels of cytokines and aGVHD were analyzed. Results: The serum levels of IL-1 and IL-2 were both increased in all 59 patients after transplantation of allogeneic hematopoietic stem cells. They were significantly higher in patients who developed grade II to IV aGVHD than those in patients who developed grade 0 to 1 aGVHD (both P <0.01). The level of IL-4 in patients with grade II to IV aGVHD had no significant difference at different time points, but it was significantly increased in patients with grade 0 to I aGVHD compared with that in patients with grade II to IV aGVHD (P <0.05). The level of TNF in patients with grade 0 to I aGVHD was not significantly different at different time points, whereas it was increased in patients with II to IV aGVHD on d 21 which was significantly higher than patients with grade 0 to I aGVHD (P <0.01). The changes in the serum levels of cytokines preceded the occurrence of aGVHD after stem cells transplantation (median time: 14 d to 21 d vs 28 d). Conclusion: The serum levels of cytokines closely correlated with the occurrence and severity of aGVHD and may be helpful for the prediction, diagnosis and monitoring of aGVHD.
