The spectrum of HPV infection in Xinjiang Uighur women with cervical cancer
- Author:
Abliz GUZALNUR
1
Author Information
1. Department of Gynecology
- Publication Type:Journal Article
- Keywords:
Papillomavirus, human;
Uterine cervical neoplasms;
Viral vaccines;
Xinjiang
- From:
Tumor
2007;27(5):379-382
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the difference in distribution of subtypes of Human papilloma virus (HPV) between cervical cancer patients and normal controls of Xinjiang Uighur women and analyze the HPV spectrum in Xinjiang Uighur women suffered from cervical cancer. Methods: Three hundred and thirty Uighur women with cervical cancer and one hundred normal healthy women were recruited in this study. Flow-through hybridization and gene chip (HybriMax) technology was used to detect the twenty one subtypes of HPV. Results: (1) The positive rate of HPV infection including simple infection and multiple infection was 85.15% (281/300) and 7.0% (7/100) in cervical cancer group and control group, respectively. The positive rate of HPV16 infection was 94.31% indicating it was the most common infection in HPV-positive cervical cancer patients. The infection rate was 5.34% for HPV18, 3.91% for HPV68, 2.49% for HPV45, 2.49% for HPV58, 2.14% for HPV39, 1.07% for HPV31, 1.07 for HPV56, and 0.36 for HPV59. There was significant difference in the total infection rate and the HPV16 infection rate between cervical cancer patients and controls (P<0.0001). (2) Twelve out of twenty one HPV subtypes were detected and the rest nine subtypes were not. The positive rate of simple infection and total infection of HPV was significantly higher in squamous cervical cancer tissues and other types of cervical cancer tissues compared with that in cervical adenocarcinoma tissues (P<0.05). While the proportion of HPV multiple infection had no statistical difference between different types of cervical cancer (P>0.05 ). Although the positive rate of multiple infection of HPV tended to increase but the difference was not significant. Conclusion: HPV16 infection was the most common in cervical cancer patients and normal controls of Xinjiang Uighur women. The next most common types of HPV were HPV18 and HPV68. Xinjiang Uighur women had the relatively higher risk of suffering HPV68 infection indicating the specificity of HPV infection in Uighur women.
