Expression of apoptosis-related protein Fas and caspase-3 in bladder transitional cell carcinoma and their clinical significance
- Author:
Yan SONG
1
Author Information
1. Department of Urology
- Publication Type:Journal Article
- Keywords:
Apoptosis regulatory proteins;
Bladder neoplasms;
Caspase-3;
Fas;
Prognosis
- From:
Tumor
2007;27(6):465-468
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the expression of apoptosis-related proteins Fas and caspase-3 in bladder transitional cell carcinoma (BTCC) and their clinical significance. Methods: The bladder tissues were isolated from 45 BTCC patients and 10 healthy controls and embedded in paraffin. The expression of Fas and caspase-3 were detected by streptavidin peroxidase inummohistochemical method. The results were analyzed associated with clinical records. Results: The positive rate of Fas expression was 46.7% (21/45) in TCC and 100% in the 10 normal bladder tissues. The positive rate of caspase-3 expression was 37. 8% (17/45) in BTCC and 90% (9/10) in normal control group. The difference was significant (P < 0.05). The expression of Fas was significantly related with the histological grades, the initiation of BTCC, either primary or recurrent, and the tumor number and but not associated with clinicopathological stages. While the expression of caspase-3 correlated with the initiation of BTCC, either primary or recurrent; but it did not correlate with the histological grades, tumor numbers, and the pathological stages of BTCC. There was a positive correlation between the expression of Fas and caspase-3 in BTCC. Conclusion: The decrease in the selective expression of Fas is closely associated with the differentiation degree of BTCC. The expression of caspase-3 is down-regulated in BTCC. Expression of Fas and caspase-3 are important to indicate the prognosis of BTCC.
