The protective effects of oxymatrine against adriamycin-induced cardiotoxicity in rabbits
- Author:
Fei MA
1
Author Information
1. Department of Oncology
- Publication Type:Journal Article
- Keywords:
Adriamycin;
Adverse drug reaction reporting systems;
Animal experimentation;
Oxymatrine
- From:
Tumor
2007;27(6):441-444
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the protective effect of oxymatrine (OMT) against chronic cardiotoxicity induced by adriamycin (ADR). Methods: Twenty six rabbits were randomly devided into four groups. The ADR group (n = 8) were injected with ADR (2 mg/kg) via auricular vein once a week for 8 weeks to induce chronic heart injury. The ADR + OMT group (n = 8) received intraveneous injection of OMT 10 mg/kg at 30 min before administration of ADR. The normal saline group (n = 5) received the same volume of 0.9% saline alone and the OMT group (n =5) received intraveneous injection of OMT alone. Before administration and 3 weeks after drug therapy, a catheter was advanced through left carotid artery and left ventricle to measure heart rate(HR), left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), and left ventricular injection fraction (LVEF). The serum was collected for determination of the activities of lactate dehydrogenase (LDH) and creatine kinase isoenzyme MB (CK-MB). The myocardial ultrastructure changes were observed by electron microscropy at 3 weeks after drug therapy. Results: Compared with ADR + OMT group, both LVSP and LVEF in ADR group were signi-ficantly decreased, but LVEDP and the activities of LDH and CK-MB were significantly increased. The difference between the two groups was significant. Pathological examination demonstrated the more severer damage of the myocardial ultrastructure in ADR group than ADR + OMT group. No adverse reaction and pathological changes were observed in OMT group. Conclusion: Oxymatrine protects heart against adriamycin-induced injury in rabbits.
