Expression of EphB4/EphrinB2 in human brain astrocytomas and its pathologic significance
- Author:
Jin-Hai GU
1
Author Information
1. Department of Neurosurgery
- Publication Type:Journal Article
- Keywords:
Astrocytoma;
Protein-tyrosine kinase;
Vascular endothelial grows factors
- From:
Tumor
2007;27(8):651-654
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the expressions of EphrinB2 and its receptor EphB4, microvessel density (MVD), and Ki-67 in human brain astrocytomas and explore their pathological significance. Methods: Expressions of EphB4/EphrinB2, MVD and Ki-67 were detected by tissue microarray and Maxvision shortcut immunohistochemical staining in 84 cases of human astrocytomas and 12 cases of traumatic brain tissues. Results: The difference was significant in expressions of EphB4/ EphrinB2, MVD and Ki-67 labeling index (LI) between human astrocytomas and controlled human traumatic brain tissues (P < 0.05). Expression of EphB4/EphrinB2, MVD and Ki-67 LI had positive cooelation with tumor grade. Ki-67 LI and MVD positively correlated with expressions of EphB4 or EphrinB2 protein (P <0. 05). Conclusion: There is a close correlation between expression of EphB4/ EphrinB2 and differentiation degree, tumor angiogenesis in human brain astrocytoma. The over-expressions of EphB4 and EphrinB2 play an important role in promoting tumor development and angiogenesis. EphB4/ EphrinB2, MVD, and Ki-67 are fine reference parameters to estimate malignancy degree and pathologic features of human brain astrocytomas.
